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The exquisite synergistic interplay between Lactobacillus and Bifidobacterium transcends mere intestinal acid–base equilibrium maintenance, orchestrating comprehensive systemic health optimization through mechanisms encompassing antimicrobial compound biosynthesis, competitive nutritional and binding site monopolization, immune regulatory cellular activation cascades, and essential enzymatic and vitamin synthetic pathways (Tian et al., 2022)

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Mechanistic studies confirm that dual amylin/calcitonin receptor activity modulates appetite and energy expenditure independently of GLP-1 signalling